Jacobson, Michael F.
Title Apoptosis: The Molecular Biology of Programmed Cell Death (Frontiers in Molecular Biology)
Book Condition New
Edition 1st Edition
Publisher Oxford University Press 2002-06-20 00:00:00.000
0199638500 / 9780199638505
Seller ID Z1-M-002-01587
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Apoptosis is a regulated form of cell demise that can be induced or blocked by groups of specific stimuli. Occurring in all living tissues, it is thought critical to the maintenance of homeostasis and is implicated in lowering susceptibility to tumour growth. Conversely, over-sensitivity to apoptotic triggers can cause cells to be lost inappropriately from tissues, as appears to occur in neurodegenerative diseases. This book examines the molecular pathways regulating apoptosis, progressing from the nematode worm through Drosphila to the more complex pathways evident in mammalian cells. Differences in the cell death pathway within specific tissues are addressed, as are the different genes that may act to regulate progressive steps.