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Phylogenetic Analysis of Viral Quasispecies
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Author Name    Buendia, Patricia

Title   Phylogenetic Analysis of Viral Quasispecies

Book Condition   New


ISBN Number    383643458X / 9783836434584

Seller ID   Z1-J-025-00838

New. Book is new and unread but may have minor shelf wear. Ships from UK in 48 hours or less (usually same day). Your purchase helps support the African Children's Educational Trust (A-CET). 100% money back guarantee. We are a world class secondhand bookstore based in Hertfordshire, United Kingdom and specialize in high quality textbooks across an enormous variety of subjects. We aim to provide a vast range of textbooks, rare and collectible books at a great price. Through our work with A-CET we have helped give hundreds of young people in Africa the vital chance to get an education. We provide a 100% money back guarantee and are dedicated to providing our customers with the highest standards of service in the bookselling industry.

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A new approach in the analysis of viral evolution is presented in this book, an approach that merges Phylogenetic analysis and Bioinformatic techniques. Patterns of viral evolution are inferred from serially-sampled sequence data, i.e., sequence data obtained from strains isolated at consecutive time points from a single patient or host. Traditional phylogenetic methods assume a tree-like evolutionary model, while many RNA viruses have the capacity to exchange genetic material with one another using a process called recombination. A genealogy involving recombination is best described by a network structure. A more general approach was implemented in a new computational tool, Sliding MinPD, one that is mindful of the sampling times of the input sequences and that reconstructs the viral evolutionary relationships in the form of a network structure with implicit representations of recombination events. The underlying network organization reveals unique patterns of viral evolution and could help explain the emergence of disease-associated mutants and drug-resistant strains, with implications for patient prognosis and treatment strategies.

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